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KMID : 0616120060370040235
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Korean Journal of Pharmacognosy
2006 Volume.37 No. 4 p.235 ~ p.240
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Anti-oxidant Activities and Anti-inflammatory Effects on Artemisia scoparia
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Yoon Weon-Jong
Lee Jung-A
Kim Ji-Young
Oh Dae-Ju
Jung Yong-Hwan
Lee Wook-Jae
Park Soo-Yeong
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Abstract
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We investigated the antioxidant activities such as DPPH radical scavenging capacity, xanthine oxidase inhibitory a ctivity, and superoxide radical scavenging capacity of the aquaeous EtOH extract and its solvent frations of Artemisia scoparia . The ethylacetate fraction showed high antioxidant activity, compared to positive controls such as ascorbic acid, butylated hydroxy anisole (BHA), trolox, and allopurinol in these assay systems. Moreover, we examined the inhibitory effect of solvent fractions of A. soparia on the production of pro-inflammatory factors that the niric oxide(NO), inducible nitric oxide synthase(iNOS), cyclooxygenase-2(COX-2) and prostaglandin E2(PGE2) production activated with LPS(1μg/ml) in murine macrophage cell line RAW264.7. The amounts of protein levels were determined by immunoblotting. In the sequential fractions of hexane and dichloromethane inhibited the NO and PGE2 production and the protein level of iNOS and COX-2. These results suggest that A. soparia may have anti-inflammatry activity through the antioxidant acivity and inhibition of pro-inflammatory factors.
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KEYWORD
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Artemisia scoparaia, NO, iNOS, COX-2, PGE2
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